Regenerative medicine can grow new, healthy tissue to heal injuries and reduce pain. Two popular regenerative treatments include stem cells and platelet-rich plasma (PRP).
Doctors prepare PRP by drawing blood and placing it in a centrifuge to separate the platelets, white blood cells and other healing components. They then inject it into the treatment area to boost your body’s natural healing powers.
Stem cells Tissue Regeneration Therapy are specialized cells that are able to develop into different types of specialized cells that form tissues and organs. They are the source of the many different cells that make up your body, from blood cells to nerve cells to bone cells.
Researchers are currently working to find ways to use stem cells to treat diseases. They want to find a way to grow replacement cells for diseased tissues, such as damaged heart tissue or brain tissue. They also hope to use stem cells to help develop new drugs. This would allow them to test a drug in living cells rather than in animals or in people who have the disease that the drug is being tested for.
Scientists have already used stem cell transplants to treat some blood conditions and some cancers. They are also investigating whether stem cells can be used to replace specialized cells in the body that have been lost due to disease or injury, such as pancreatic beta cells for diabetes or dopamine-producing neurons for Parkinson’s disease.
Stem cells have the potential to transform our understanding of human health and disease, especially those that occur because of abnormal cell division. However, there are some concerns regarding the use of stem cells for therapy. For example, if the stem cells are not from a donor who is matched to your tissue type, there is a risk of rejection of the transplanted cells by your immune system. This is known as graft-versus-host disease. Researchers are investigating how to reduce the risk of this reaction by using different methods to produce transplantable cells, including genetic reprogramming of regular adult cells into stem cells.
Platelets are specialized blood cells that form clots to stop bleeding in wounded tissues. This function is essential for patients undergoing surgeries like organ transplants, fighting cancer or surviving serious injuries from accidents or trauma.
Unlike red and white blood cells, platelets are a colorless cell fragment without a nucleus. They are disk-shaped and do not circulate independently, but instead act in concert with other blood cells to form a plug that fixes damaged blood vessels or wounds. They do this by sensing a chemical signal (ligands) from damaged blood vessels that attract platelets to the site of damage and initiate a chain reaction that results in the formation of a blood clot (thrombus).
The number of platelets in your body is normally between 150,000 and 450,000 per microliter of your blood. This is determined through a blood test called a complete blood count (CBC) or a blood smear where a sample of your blood is examined under a microscope. If the number of platelets is too low, this condition is called thrombocytopenia. It can be caused by a condition or disease that prevents your bone marrow from making enough platelets, such as aplastic anemia. Other conditions, such as lupus and rheumatoid arthritis, may also reduce your platelet count.
If you have too few platelets, your doctor may give you donated platelets through a process known as platelet apheresis. This involves drawing a small amount of blood from one arm and running it through a centrifuge machine that separates and collects the platelets while returning the remaining blood components to your body through the other arm. This ensures that you receive only the platelets you need, reducing your risk of developing a blood-borne disease or other problems.
Platelet-rich plasma (PRP) is a concentrated mixture of blood plasma that contains several different growth factors. These factors stimulate and encourage the production of new cells at the site of injury. PRP also reduces inflammation and can alleviate pain. It is a safe and effective treatment for many patients. It is especially useful for those who cannot or do not want to undergo surgery, or for whom other medications are ineffective.
A PRP injection begins with a small amount of blood being drawn from your body and placed in a centrifuge to separate the platelets from the rest of the blood. The concentration of platelets is then injected into the area of your body that needs healing. Your doctor may use ultrasound technology to help guide the injection. The process takes less than an hour. You may feel some discomfort at the injection site for a few days, but this is normal.
In some cases, your doctor might mix PRP with stem cells to enhance its effectiveness. The treatment can be used to treat a wide variety of conditions, including osteoarthritis (OA), rheumatoid arthritis, sports injuries, and even hair loss. It works best for localized musculoskeletal problems. It can help heal damaged muscles, ligaments, tendons, joints, and cartilage. It can also increase the regenerative abilities of your skin by reducing wrinkles and improving skin texture.
The field of oral surgery focuses on performing surgical procedures that deal with the mouth, jaw and face. This includes tooth extractions, removing diseased or impacted teeth and treating gum diseases like periodontitis. Oral surgeons can also help patients with facial injuries, breathing problems, tumor removal and reconstructive surgery following accidents.
Traditionally, standard oral surgery techniques have involved replacing deteriorated tissue with autologous grafts from living donors or cadavers. This is a very expensive and time-consuming process with a potential for complications such as infections and rejection from the body [1].
Plasma rich in growth factors (PRGF) is a concentrated sample of your own blood that contains highly active proteins that stimulate cell repair and promote tissue regeneration. The plasma is separated from the rest of your blood by spinning it in a centrifuge and then added back into your mouth as a topical gel to encourage Health healing.
Studies using PRGF have shown significant improvements in wound healing and bone regeneration compared to conventional methods. Bone marrow mesenchymal stem cells (BMSCs) have also been used in the field of oral and maxillofacial surgery. Several studies have demonstrated improved bone formation after the application of BMSCs on a gelatin sponge for extraction sockets, and in intrabony periodontal regeneration after the use of a PLGA-HA scaffold containing hemicellulose [37]. [38] Similarly, Baena et al. demonstrated improved bone formation in maxillary sinus floor elevation surgery after periosteum-derived stem cells were combined with a PLGA-HA scaffold, compared to the control group that received a saline-soaked gelatin sponge.
